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E., Chen, C
Compared with the healthy mice, there was a significant increase in the serum levels of PGE2, CRP, TNF- and IL-6 in the mice with cachexia receiving saline
Nonetheless, the aforementioned animal models, although extremely useful in investigating specific molecular mechanisms in the pathogenesis of ulcerative colitis, do not truly recapitulate disease as observed in patients, as IBD is a multifactorial disease and most clearly is not caused by a single mutation or defect in cellular or molecular pathways
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